After a 62-20 loss at the hands of No. 10 Utah, the Ducks (2-2, 0-1 Pac-12) are unranked for the first time since 2009, snapping a 98-game streak of making the Top 25.  Oregon looked shell-shocked in the loss, struggling on both offense and defense as the Utes ran away in the route.
The Ducks will be looking to rebound on the road against Colorado (3-1), a team that is coming off a successful showing against Nicholls State. The Buffalo were able to force the Colonels into committing three costly turnovers and convincingly won, 48-0.
The last time these two teams played, Oregon won 44-10, with former Ducks Heisman trophy winner Marcus Mariota scoring four touchdowns.
But this will be a much different Ducks team going into Boulder, Colorado. On the season, Oregon averages 240.2 passing yards (62nd) and 285.2 rushing yards (11th) per game, while Colorado averages 205.5 passing yards (87th) and 272.0 rushing yards (13th).
Here are the match-ups to watch on Saturday:
 Oregon’s defensive front seven vs. Colorado’s offensive line
Against Utah, Oregon struggled to collapse the pocket, allowing quarterback Travis Wilson plenty of time to set his feet and let the routes develop. Against Colorado, the Ducks will have to find ways to put pressure on starting quarterback Sefo Liufau. As a team, Oregon has recorded just five sacks through four games.
 Oregon’s quarterback vs. Colorado’s secondary
Whoever lines up behind center for the Ducks — whether it is Vernon Adams Jr. or Jeff Lockie — needs to be able to open up the playbook and get the offense moving. The offense looked stagnant in its loss last week. On the other side of the ball, Colorado’s secondary has been excellent,  recording seven interceptions this season.
 Players to watch:
 Oregon:
 Royce Freeman, running back 
With so much uncertainty in the passing game, the Ducks may focus on the run Saturday. Freeman should be the workhorse, making an impact early. He has rushed for 450 yards and five touchdowns in 2015, though against Utah, he was held to his lowest total of the season – 77 yards.
 Colorado:
 Nelson Spruce, wide receiver
It should be no surprise that one of the main players to watch when a team plays Oregon is the top wide receiver — as the Oregon secondary has made a habit of giving up big numbers of late. Colorado senior Nelson Spruce is poised to have a monster performance. He has a good balance of size and speed, while using crisp route running to shake off opposing defenders. Last year, Spruce racked up 1,198 receiving yards and 12 touchdowns, a performance good enough to make him a semifinalist for the Biletnikoff Award, which is given to the nation’s best receiver.
 Diego Gonzalez, kicker
One dangerous area of Colorado’s game is special teams, where their kicker Gonzalez has sent some big attempts sailing through the uprights. On the season, the junior is kicking 72.7 percent, and is a perfect 16-for-16 on extra points. Most impressive is his range, as all of his makes have come from at least 30 yards out. He is 4-of-5  from beyond 40 yards, with a season long currently at 52 yards. Gonzalez ensures that Colorado will be putting points on the board even if the offense fails to punch it in.
Follow Christopher Keizur on Twitter @christopherkeizur